Elevated histone expression promotes life span extension.

@article{Feser2010ElevatedHE,
  title={Elevated histone expression promotes life span extension.},
  author={Jason M Feser and David Truong and Chandrima Das and Jasmine Carson and Jeffrey S Kieft and Troy A Harkness and Jessica K Tyler},
  journal={Molecular cell},
  year={2010},
  volume={39 5},
  pages={
          724-35
        }
}
Changes to the chromatin structure accompany aging, but the molecular mechanisms underlying aging and the accompanying changes to the chromatin are unclear. Here, we report a mechanism whereby altering chromatin structure regulates life span. We show that normal aging is accompanied by a profound loss of histone proteins from the genome. Indeed, yeast lacking the histone chaperone Asf1 or acetylation of histone H3 on lysine 56 are short lived, and this appears to be at least partly due to their… CONTINUE READING
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