Elevated heat shock protein 60 levels are associated with higher risk of coronary heart disease in Chinese.

@article{Zhang2008ElevatedHS,
  title={Elevated heat shock protein 60 levels are associated with higher risk of coronary heart disease in Chinese.},
  author={Xiaomin Zhang and Mei'an He and Longxian Cheng and Yin Chen and Li Zhou and Hesong Zeng and Alan Graham Pockley and Frank B Hu and Tangchun Wu},
  journal={Circulation},
  year={2008},
  volume={118 25},
  pages={2687-93}
}
BACKGROUND Although heat shock protein 60 (Hsp60) is implicated in the pathogenesis of atherosclerosis, its role in coronary heart disease (CHD) is uncertain. This study explored the influence of circulating Hsp60 on CHD in a large case-control study, as well as the impact of acute myocardial infarction on Hsp60 levels in a prospective study. METHODS AND RESULTS Plasma Hsp60 and anti-Hsp60 antibody levels were determined by immunoassay. In the case-control study (1003 patients with CHD, 1003… CONTINUE READING