Elevated granulocyte manganese in rheumatoid arthritis and other connective tissue diseases.

@article{Hllgren1985ElevatedGM,
  title={Elevated granulocyte manganese in rheumatoid arthritis and other connective tissue diseases.},
  author={Roger H{\"a}llgren and Karen L Svenson and Erland Johansson and Ulf Lindh},
  journal={The Journal of rheumatology},
  year={1985},
  volume={12 5},
  pages={876-80}
}
Higher than normal amounts (p less than 0.001) of manganese were found in granulocytes isolated from patients with rheumatoid arthritis, other inflammatory arthritides, and scleroderma, while erythrocytes and platelets contained normal amounts of manganese. The cause of manganese accumulation is not known but evidently is linked to the intensity of the inflammatory process since significant positive correlations (p less than 0.001) were seen between erythrocyte sedimentation rate or serum… CONTINUE READING