Elevated glutathione level does not protect against chronic alcohol mediated apoptosis in recombinant human hepatoma cell line VL-17A over-expressing alcohol metabolizing enzymes--alcohol dehydrogenase and Cytochrome P450 2E1.

@article{Chandrasekaran2011ElevatedGL,
  title={Elevated glutathione level does not protect against chronic alcohol mediated apoptosis in recombinant human hepatoma cell line VL-17A over-expressing alcohol metabolizing enzymes--alcohol dehydrogenase and Cytochrome P450 2E1.},
  author={Karthikeyan Chandrasekaran and Kavitha Swaminathan and S. Mathan Kumar and Suvro Chatterjee and Dahn L. Clemens and Aparajita Dey},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2011},
  volume={25 4},
  pages={
          969-78
        }
}
  • Karthikeyan Chandrasekaran, Kavitha Swaminathan, +3 authors Aparajita Dey
  • Published 2011
  • Chemistry, Medicine
  • Toxicology in vitro : an international journal published in association with BIBRA
  • Chronic consumption of alcohol leads to liver injury. Ethanol-inducible Cytochrome P450 2E1 (CYP2E1) plays a critical role in alcohol mediated oxidative stress due to its ability to metabolize ethanol. In the present study, using the recombinant human hepatoma cell line VL-17A that over-expresses the alcohol metabolizing enzymes-alcohol dehydrogenase (ADH) and CYP2E1; and control HepG2 cells, the mechanism and mode of cell death due to chronic ethanol exposure were studied. Untreated VL-17A… CONTINUE READING

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