Elevated gene expression of Th1/Th2 associated transcription factors is correlated with disease activity in patients with systemic lupus erythematosus.

@article{Lit2007ElevatedGE,
  title={Elevated gene expression of Th1/Th2 associated transcription factors is correlated with disease activity in patients with systemic lupus erythematosus.},
  author={Lydia Choi-Wan Lit and Chun-kwok Wong and Edmund Kwok-Ming Li and L O Tam and C. K. Lam and Yuk-Ming Dennis Lo},
  journal={The Journal of rheumatology},
  year={2007},
  volume={34 1},
  pages={89-96}
}
OBJECTIVE T-box expressed in T cells (T-bet) and GATA-binding protein 3 (GATA-3) are transcriptional factors that play a crucial role in Th1 and Th2 development. We investigated the immunomodulatory roles of T-bet and GATA-3 and Th1/Th2 related cytokines in the pathogenesis of systemic lupus erythematosus (SLE) and their association with disease activity. METHODS Gene expressions of T-bet, GATA-3, interferon-gamma (IFN-gamma), and interleukin 4 (IL-4) in peripheral blood mononuclear cells… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

Transcription factors in autoimmune diseases.

Frontiers in bioscience : a journal and virtual library • 2008
View 7 Excerpts
Highly Influenced

Polarization of Helper T Lymphocytes Maybe Involved in the Pathogenesis of Lumbar Disc Herniation.

Iranian journal of allergy, asthma, and immunology • 2017
View 1 Excerpt

Similar Papers

Loading similar papers…