Elevated gamma-aminobutyric acid levels attenuate the metabolic response to bilateral ischemia.

@article{Abel1992ElevatedGA,
  title={Elevated gamma-aminobutyric acid levels attenuate the metabolic response to bilateral ischemia.},
  author={Marc S. Abel and David McCandless},
  journal={Journal of neurochemistry},
  year={1992},
  volume={58 2},
  pages={740-4}
}
Bilateral ischemia has been shown to alter the net brain levels of energy metabolites such as ATP, phosphocreatine, glucose, and glycogen. The amino acid neurotransmitter gamma-aminobutyric acid (GABA) exerts a tonic inhibitory influence on neural activity. The present studies were designed to evaluate the influence of elevated GABA levels on the metabolic sequelae of ischemia. The GABA transaminase inhibitor gamma-vinyl-GABA (GVG; vigabatrin) was administered to Mongolian gerbils before the… CONTINUE READING