Elevated frequencies of highly activated CD4+ T cells in HIV+ patients developing immune reconstitution inflammatory syndrome.

@article{Antonelli2010ElevatedFO,
  title={Elevated frequencies of highly activated CD4+ T cells in HIV+ patients developing immune reconstitution inflammatory syndrome.},
  author={Lis Ribeiro do Valle Antonelli and Yolanda D. Mahnke and Jessica N. Hodge and Brian O. Porter and Daniel L Barber and Rebecca Dersimonian and Jamieson H Greenwald and Gregg Roby and Joann M Mican and Alan Sher and Mario Roederer and Irini Sereti},
  journal={Blood},
  year={2010},
  volume={116 19},
  pages={3818-27}
}
Immune reconstitution inflammatory syndrome (IRIS) is a considerable problem in the treatment of HIV-infected patients. To identify immunologic correlates of IRIS, we characterized T-cell phenotypic markers and serum cytokine levels in HIV patients with a range of different AIDS-defining illnesses, before and at regular time points after initiation of antiretroviral therapy. Patients developing IRIS episodes displayed higher frequencies of effector memory, PD-1(+), HLA-DR(+), and Ki67(+) CD4… CONTINUE READING