Elevated formation of pyridinoline cross-links by profibrotic cytokines is associated with enhanced lysyl hydroxylase 2b levels.

@article{Slot2005ElevatedFO,
  title={Elevated formation of pyridinoline cross-links by profibrotic cytokines is associated with enhanced lysyl hydroxylase 2b levels.},
  author={Annemarie J van der Slot and Ernst A van Dura and Elly C M de Wit and Jeroen de Groot and Tom W. J. Huizinga and Ruud A. Bank and A Zuurmond},
  journal={Biochimica et biophysica acta},
  year={2005},
  volume={1741 1-2},
  pages={95-102}
}
The hallmark of fibrosis is the excessive accumulation of collagen. The deposited collagen contains increased pyridinoline cross-link levels due to an overhydroxylation of lysine residues within the collagen telopeptides. Lysyl hydroxylase 2b (LH2b) is the only lysyl hydroxylase consistently up-regulated in several forms of fibrosis, suggesting that an enhanced LH2b level is responsible for the overhydroxylation of collagen telopeptides. The present paper reports the effect of profibrotic… CONTINUE READING

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