Elevated factor VIII levels and risk of venous thrombosis

@article{Jenkins2012ElevatedFV,
  title={Elevated factor VIII levels and risk of venous thrombosis},
  author={P. Vince Jenkins and Orla Rawley and Owen P. Smith and James S. O’Donnell},
  journal={British Journal of Haematology},
  year={2012},
  volume={157}
}
Modern thrombophilia testing fails to identify any underlying prothrombotic tendency in a significant number of patients presenting with objectively confirmed venous thromboemboembolism (VTE). This observation has led to a search for other novel inherited or acquired human thrombophilias. Although a number of putative mechanisms have been described, the evidence behind many of these candidates remains weak. In contrast, an increasing body of work supports the hypothesis that increased plasma… Expand
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Elevated plasma levels of factor VIIIc are a significant, prevalent, independent and dose-dependent risk factor for venous thromboembolism and it also predisposes to recurrent venous Thrombosis. Expand
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FVIII levels seem to be familially determined in families in which a member showed high FVIIILevels after previous venous thromboembolism, and multiple regressive analysis of blood donors and asymptomatic family members showed that the affiliation with a family in which 1 member suffered from venousThrombotic event and had reproducibly high F VIII levels is the second most important predictor for FV III levels. Expand
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Elevated plasma FVIII level is a risk factors for VTE in Japanese people, and FV III levels above the 75(th) percentile are associated with a significant odds ratio for the occurrence of VTE. Expand
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