Elevated expression of vascular endothelial growth factor correlates with increased angiogenesis and decreased progression-free survival among patients with low-grade neuroendocrine tumors.

@article{Zhang2007ElevatedEO,
  title={Elevated expression of vascular endothelial growth factor correlates with increased angiogenesis and decreased progression-free survival among patients with low-grade neuroendocrine tumors.},
  author={Jun Zhang and Zhiliang Jia and Qiang Li and Liwei Wang and Asif Rashid and Zheng-gang Zhu and Douglas B. Evans and J. Nicholas Vauthey and Keping Xie and James C. Yao},
  journal={Cancer},
  year={2007},
  volume={109 8},
  pages={1478-86}
}
BACKGROUND Vascular endothelial growth factor (VEGF) is a critical proangiogenic factor in solid tumors. However, its expression and role in human neuroendocrine tumor development and progression remains unclear. METHODS Using immunohistochemistry, VEGF and Sp1 expression patterns were investigated in 50 cases of human gastrointestinal neuroendocrine tumor having various clinicopathologic characteristics. RESULTS It was found that strong VEGF expression was detected in tumor cells, whereas… CONTINUE READING