Elevated expression of urotensin II and its receptor in diethylnitrosamine-mediated precancerous lesions in rat liver

  title={Elevated expression of urotensin II and its receptor in diethylnitrosamine-mediated precancerous lesions in rat liver},
  author={Hongxia Wang and Kung Dong and Xiaowei Xue and P. Feng and Xuejian Wang},
Urotensin II (UII) is a somatostatin-like peptide involved in cell proliferation and in tumor biology. To explore the role of liver-derived UII in the pathogenesis of precancerous liver lesions in rat, we investigated the expression of UII and its receptor, UT, in diethylnitrosamine (DEN)-induced precancerous liver lesions and the effects of UII on cell proliferation by hepatic oval cells. Radioimmunoassay, RT-PCR, immunohistochemistry and western blot were used in this study. Compared with… Expand
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The G Protein-Coupled Receptor UT of the Neuropeptide Urotensin II Displays Structural and Functional Chemokine Features
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Urotensin II receptor determines prognosis of bladder cancer regulating cell motility/invasion
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Urotensin‐II receptor is over‐expressed in colon cancer cell lines and in colon carcinoma in humans
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Co-expression of urotensin II and its receptor (GPR14) in human cardiovascular and renal tissues
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Immunolocalization of urotensin II and its receptor in human adrenal tumors and attached non-neoplastic adrenal tissues
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UII and its receptor GPR14 exert a possible effect in the pathogenesis of pheochromocytoma, which is lower than that in normal adrenal tissues. Expand
Urotensin II is an autocrine/paracrine growth factor for the porcine renal epithelial cell line, LLCPK1.
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Expression of urotensin II and its receptor in adrenal tumors and stimulation of proliferation of cultured tumor cells by urotensin II
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Role of urotensin II in peripheral tissue as an autocrine/paracrine growth factor
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