Elevated expression of urotensin II and its receptor in diethylnitrosamine-mediated precancerous lesions in rat liver

@article{Wang2011ElevatedEO,
  title={Elevated expression of urotensin II and its receptor in diethylnitrosamine-mediated precancerous lesions in rat liver},
  author={Hongxia Wang and Kung Dong and Xiaowei Xue and P. Feng and Xuejian Wang},
  journal={Peptides},
  year={2011},
  volume={32},
  pages={382-387}
}
Urotensin II (UII) is a somatostatin-like peptide involved in cell proliferation and in tumor biology. To explore the role of liver-derived UII in the pathogenesis of precancerous liver lesions in rat, we investigated the expression of UII and its receptor, UT, in diethylnitrosamine (DEN)-induced precancerous liver lesions and the effects of UII on cell proliferation by hepatic oval cells. Radioimmunoassay, RT-PCR, immunohistochemistry and western blot were used in this study. Compared with… Expand
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