Elevated expression of transglutaminase 1 and keratinization-related proteins in conjunctiva in severe ocular surface disease.

@article{Nakamura2001ElevatedEO,
  title={Elevated expression of transglutaminase 1 and keratinization-related proteins in conjunctiva in severe ocular surface disease.},
  author={Toshinobu Nakamura and Kohji Nishida and Atsuyoshi Dota and Masato Matsuki and Kiyofumi Yamanishi and Shigeru Kinoshita},
  journal={Investigative ophthalmology & visual science},
  year={2001},
  volume={42 3},
  pages={549-56}
}
PURPOSE In severe ocular surface diseases, pathologic keratinization of the ordinarily nonkeratinized corneal and conjunctival mucosal epithelia results in severe visual loss. The expression in conjunctivalized corneas of various proteins known to play important roles in the physiological keratinization process in human epidermis was examined to better understand the mechanism of keratinization. METHODS Conjunctiva covering the cornea was examined in 12 eyes with ocular surface disease in the… CONTINUE READING

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