Elevated expression of surfactant proteins in newborn rats during adaptation to hyperoxia.

@article{White2001ElevatedEO,
  title={Elevated expression of surfactant proteins in newborn rats during adaptation to hyperoxia.},
  author={Carl W. White and Kelly E. Greene and Corrie B Allen and John M. Shannon},
  journal={American journal of respiratory cell and molecular biology},
  year={2001},
  volume={25 1},
  pages={51-9}
}
The mechanisms whereby lung adaptation to hyperoxia occurs in the newborn period are incompletely understood. Pulmonary surfactant has been implicated in lung protection against hyperoxic injury, and elevated expression of certain surfactant proteins occurs in lungs of adult rats during adaptation to sublethal oxygen (85% O(2)). Here we report that newborn rats, which can adapt to even higher levels of hyperoxia (100% O(2)) than do adult rats, manifest changes in the lung surfactant proteins… CONTINUE READING

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