Elevated expression of p21ras is an early event in Alzheimer's disease and precedes neurofibrillary degeneration.

@article{Grtner1999ElevatedEO,
  title={Elevated expression of p21ras is an early event in Alzheimer's disease and precedes neurofibrillary degeneration.},
  author={Ulrich G{\"a}rtner and Max Holzer and Thomas Arendt},
  journal={Neuroscience},
  year={1999},
  volume={91 1},
  pages={1-5}
}
Alzheimer's disease is a chronic degenerative disorder characterized by the intracellular accumulation of "paired helical filaments" consisting of highly phosphorylated tau and by extracellular deposits of aggregated Abeta-peptide. Furthermore, neurodegeneration in Alzheimer's disease is associated with the appearance of neuritic growth profiles that are aberrant with respect to their localization, morphological appearance, and composition of cytoskeletal elements. During early stages of… CONTINUE READING

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