Elevated expression of hTERT is associated with dysplastic cell transformation during human oral carcinogenesis in situ.

@article{Kim2001ElevatedEO,
  title={Elevated expression of hTERT is associated with dysplastic cell transformation during human oral carcinogenesis in situ.},
  author={H R Kim and R Christensen and P Sapp and M K Kang and N H Park},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2001},
  volume={7 10},
  pages={3079-86}
}
  • H R Kim, R Christensen, +2 authors N H Park
  • Published 2001 in
    Clinical cancer research : an official journal of…
PURPOSE Telomerase is a ribonucleoprotein complex composed of the catalytic protein subunit (human telomerase reverse transcriptase or hTERT) and the RNA template. This enzyme activity is a necessary and rate-limiting step of cellular immortalization and could provide a unique marker of aberrant cells, which may selectively be targeted. The current study was undertaken to quantitatively determine the degree of telomerase activation during multistage oral carcinogenesis using paraffin-embedded… CONTINUE READING