Elevated expression of CYP1A1 and gamma-SYNUCLEIN in human ectopic (ovarian) endometriosis compared with eutopic endometrium.

@article{Singh2008ElevatedEO,
  title={Elevated expression of CYP1A1 and gamma-SYNUCLEIN in human ectopic (ovarian) endometriosis compared with eutopic endometrium.},
  author={Madhurendra N. Singh and Helen F. Stringfellow and Si{\^a}n E. Taylor and Kate M Ashton and Mushfika Ahmad and Khalil R Abdo and O M A El-Agnaf and Pierre Leonard Martin-Hirsch and Francis Luke Martin},
  journal={Molecular human reproduction},
  year={2008},
  volume={14 11},
  pages={
          655-63
        }
}
Endometriosis is a debilitating disease in which apoptotic, genetic, immunological, angiogenic and environmental factors have been implicated. Endocrine-disrupting agents (e.g. dioxins) might be involved. Dioxins, via the arylhydrocarbon receptor (AhR), induce estrogen-metabolizing enzymes CYP1A1 and CYP1B1. Elevated expression of gamma-SYNUCLEIN (gamma-SYN) has been associated with hormone-related conditions. Tissue sets consisting of eutopic and ectopic (ovarian) endometrium from patients… CONTINUE READING
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