Elevated endothelial microparticles in thrombotic thrombocytopenic purpura: findings from brain and renal microvascular cell culture and patients with active disease.

@article{Jimenez2001ElevatedEM,
  title={Elevated endothelial microparticles in thrombotic thrombocytopenic purpura: findings from brain and renal microvascular cell culture and patients with active disease.},
  author={Joaquin J Jimenez and Wenche Jy and Lucia M. Mauro and Lawrence L. Horstman and Yeon Soong Ahn},
  journal={British journal of haematology},
  year={2001},
  volume={112 1},
  pages={81-90}
}
Endothelial injury is believed to be a key initiating event in the pathogenesis of thrombotic thrombocytopenic purpura (TTP), leading to platelet activation and formation of platelet-rich thrombi in microvasculature. However, the nature of endothelial injury in TTP is poorly defined and clinical assays to rapidly and reliably monitor endothelial damage are not readily available. Using flow cytometry, we measured endothelial microparticles (EMPs) generated from cultured renal and brain… CONTINUE READING

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