Elevated endogenous cannabinoids in schizophrenia.

@article{Leweke1999ElevatedEC,
  title={Elevated endogenous cannabinoids in schizophrenia.},
  author={F. Markus Leweke and Andrea Giuffrida and Ullrich Wurster and Hinderk M. Emrich and Daniele Piomelli},
  journal={Neuroreport},
  year={1999},
  volume={10 8},
  pages={1665-9}
}
Evidence suggests that cannabinoid receptors, the pharmacologcial target of cannabis-derived drugs, and their accompanying system of endogenous activators may be dysfunctional in schizophrenia. To test this hypothesis, we examined whether endogenous cannabinoid concentrations in cerebrospinal fluid of schizophrenic patients are altered compared to nonschizophrenic controls. Endogenous cannabinoids were purified from cerebrospinal fluid of 10 patients with schizophrenia and 11 non-schizophrenic… CONTINUE READING
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ACKNOWLEDGEMENTS: Funded by grants from the National Institute of Drug Abuse (DA 12447 and DA 12431) and Roche Bioscience to D.P

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