Elevated cyclin E levels, inactive retinoblastoma protein, and suppression of the p27(KIP1) inhibitor characterize early development of promyeloid cells into macrophages.

@article{Liu1999ElevatedCE,
  title={Elevated cyclin E levels, inactive retinoblastoma protein, and suppression of the p27(KIP1) inhibitor characterize early development of promyeloid cells into macrophages.},
  author={Qin Liu and R W Vanhoy and J H Zhou and Robert Dantzer and Gregory G Freund and Keith W. Kelley},
  journal={Molecular and cellular biology},
  year={1999},
  volume={19 9},
  pages={6229-39}
}
Cyclin-dependent kinase inhibitors such as p27(KIP1) have recently been shown to lead to cellular differentiation by causing cell cycle arrest, but it is unknown whether similar events occur in differentiating promyeloid cells. Hematopoietic progenitor cells undergo lineage-restricted differentiation, which is accompanied by expression of distinct maturation markers. Here we show that the classical growth factor insulin-like growth factor I (IGF-I) potently promotes vitamin D(3)-induced… CONTINUE READING

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