Elevated cyclin D1 expression is governed by plasma IGF-1 through Ras/Raf/MEK/ERK pathway in rumen epithelium of goats supplying a high metabolizable energy diet.


The objective of this study was to explore the underlying mechanism of insulin-like growth factor 1 (IGF-1)-caused cell proliferation of rumen epithelium in goats fed a high metabolizable energy (ME) diet. In this study, young goats were fed either a low ME [LL, n = 9, ME: 0.57 MJ/kg(0.75) /day] or high ME [HL, n = 9, ME: 1.00 MJ/(kg(0.75) /day)] diet for… (More)
DOI: 10.1111/jpn.12026