Elevated cyclic adenosine monophosphate ameliorates ischemia-reperfusion injury in rat cardiac allografts.

@article{Murata2003ElevatedCA,
  title={Elevated cyclic adenosine monophosphate ameliorates ischemia-reperfusion injury in rat cardiac allografts.},
  author={Seiichiro Murata and Douglas N. Miniati and Murray H Kown and Mark L Koransky and Leora B Balsam and Maarten A. Lijkwan and Jasper M. Martens and Robert Clayton Robbins},
  journal={The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation},
  year={2003},
  volume={22 7},
  pages={802-9}
}
BACKGROUND Oxidative stress after ischemia and reperfusion leads to leukocyte activation, the production of injurious cytokines, and increased expression of inflammatory adhesion molecules. This initial event is one of the most important alloantigen-independent factors associated with graft coronary artery disease (GCAD). Cyclic adenosine monophosphate… CONTINUE READING