Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophages.

  title={Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophages.},
  author={Angie L. Hertz and Andrew T Bender and Kimberly C. Smith and Mark Gilchrist and Paul S. Amieux and Alan Aderem and Joseph A. Beavo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 51},
Macrophages are central mediators of the innate immune system that can be differentiated from monocytes upon exposure to cytokines. While increased cyclic adenosine monophosphate (cAMP) levels are known to inhibit many lipopolysaccharide-elicited macrophage inflammatory responses, the effects of elevated cAMP on monocyte/macrophage differentiation are not as well understood. We show here that during differentiation, cAMP agonists can cause a large increase in the mRNA and protein levels of… CONTINUE READING


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