Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophages.

@article{Hertz2009ElevatedCA,
  title={Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophages.},
  author={Angie L. Hertz and Andrew T Bender and Kimberly C. Smith and Mark Gilchrist and Paul S. Amieux and Alan Aderem and Joseph A. Beavo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 51},
  pages={21978-83}
}
Macrophages are central mediators of the innate immune system that can be differentiated from monocytes upon exposure to cytokines. While increased cyclic adenosine monophosphate (cAMP) levels are known to inhibit many lipopolysaccharide-elicited macrophage inflammatory responses, the effects of elevated cAMP on monocyte/macrophage differentiation are not as well understood. We show here that during differentiation, cAMP agonists can cause a large increase in the mRNA and protein levels of… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 45 references

Immunology of asthma and chronic obstructive pulmonary disease

Nature Reviews Immunology • 2008
View 7 Excerpts
Highly Influenced

Chemokine receptors as therapeutic targets in chronic obstructive pulmonary disease.

Trends in pharmacological sciences • 2006
View 8 Excerpts
Highly Influenced

Adenosine receptors and asthma.

Handbook of experimental pharmacology • 2009

Chemokine receptor antagonists: overcoming developmental hurdles

Nature Reviews Drug Discovery • 2009
View 1 Excerpt

Cyclic AMP: master regulator of innate immune cell function.

American journal of respiratory cell and molecular biology • 2008
View 3 Excerpts

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