Elevated corticosterone levels. A possible cause of reduced axon sprouting in aged animals.

@article{DeKosky1984ElevatedCL,
  title={Elevated corticosterone levels. A possible cause of reduced axon sprouting in aged animals.},
  author={Steven DeKosky and Stephen William Scheff and Carl Cotman},
  journal={Neuroendocrinology},
  year={1984},
  volume={38 1},
  pages={33-8}
}
Measurements of serum corticosterone taken at three times in the diurnal cycle (08.00, 18.00, and 23.30 h) showed that aged male Sprague-Dawley rats have higher nonstressed circulating levels at two time points measured. To determine if such elevated levels of steroids were sufficient to interfere with lesion-induced sprouting, the corticosterone peak at 18.00 h of either aged or young adult animals was maintained in young adrenalectomized rats by use of subcutaneous corticosterone pellets. The… CONTINUE READING

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