Elevated cortical zinc in Alzheimer disease.

  title={Elevated cortical zinc in Alzheimer disease.},
  author={Dorota Religa and Dorothea Strozyk and Robert Alan Cherny and Irene Volitakis and Vahram Haroutunian and Bengt Winblad and John A Naslund and Ashley I. Bush},
  volume={67 1},
OBJECTIVE To determine whether changes in brain biometals in Alzheimer disease (AD) and in normal brain tissue are tandemly associated with amyloid beta-peptide (Abeta) burden and dementia severity. METHODS The authors measured zinc, copper, iron, manganese, and aluminum and Abeta levels in postmortem neocortical tissue from patients with AD (n = 10), normal age-matched control subjects (n = 14), patients with schizophrenia (n = 26), and patients with schizophrenia with amyloid (n = 8… CONTINUE READING
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