Elevated circulating tumor necrosis factor-alpha in patients with Kawasaki disease.

@article{Maury1989ElevatedCT,
  title={Elevated circulating tumor necrosis factor-alpha in patients with Kawasaki disease.},
  author={Carl Peter J Maury and E P I Salo and Pirkko Pelkonen},
  journal={The Journal of laboratory and clinical medicine},
  year={1989},
  volume={113 5},
  pages={651-4}
}
The mechanism of vascular injury in Kawasaki disease (KD) is unclear. Recent studies suggest a role for circulating antibodies that are cytotoxic for endothelial cell antigens inducible by cytokines. Tumor necrosis factor-alpha (TNF, cachectin) is a monocyte- or macrophage-derived cytokine that has an important role as an effector molecule in various inflammatory processes. To study the possible involvement of TNF in KD, we measured the levels of circulating TNF in 39 patients with KD at… CONTINUE READING
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