Elevated circulating levels of matrix metalloproteinases MMP-2 and MMP-9 in pseudoxanthoma elasticum patients

@article{Diekmann2009ElevatedCL,
  title={Elevated circulating levels of matrix metalloproteinases MMP-2 and MMP-9 in pseudoxanthoma elasticum patients},
  author={Ulf Diekmann and Ralf Zarbock and Doris Hendig and Christiane Szliska and Knut Kleesiek and Christian G{\"o}tting},
  journal={Journal of Molecular Medicine},
  year={2009},
  volume={87},
  pages={965-970}
}
Pseudoxanthoma elasticum (PXE) is a rare disorder predominantly affecting the skin, the eyes, and the cardiovascular system. The disease is caused by mutations in the ABCC6 gene and characterized by ectopic calcification and extracellular matrix (ECM) alterations. Matrix metalloproteinases (MMPs) play a pivotal role in the process of ECM remodeling. In the present study, we investigated matrix metalloproteinases MMP-2 and MMP-9 in PXE patients compared to healthy controls. We analyzed the serum… CONTINUE READING

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