Elevated cholesterol levels in the plasma membranes of macrophages inhibit migration by disrupting RhoA regulation.

@article{Nagao2007ElevatedCL,
  title={Elevated cholesterol levels in the plasma membranes of macrophages inhibit migration by disrupting RhoA regulation.},
  author={Tomokazu Nagao and Chunbo Qin and Inna Grosheva and Frederick R Maxfield and Lynda M. Pierini},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2007},
  volume={27 7},
  pages={1596-602}
}
OBJECTIVE Atherogenesis begins as small subendothelial accumulations of foam cells that develop through unregulated uptake of modified and aggregated low-density lipoprotein (LDL). The reason why foam cells remain in the atherosclerotic plaque rather than migrating out of the area is unclear. We tested the hypothesis that elevated membrane cholesterol levels, which may result from interactions with aggregated LDL, affect macrophage migration. METHODS AND RESULTS Cholesterol loading by… CONTINUE READING

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