Elevated cerebrospinal fluid tumour necrosis factor is associated with acute and long-term neurocognitive impairment in cerebral malaria.

@article{Shabani2017ElevatedCF,
  title={Elevated cerebrospinal fluid tumour necrosis factor is associated with acute and long-term neurocognitive impairment in cerebral malaria.},
  author={E HashemiSheikh Shabani and Benson J. Ouma and Richard Idro and Paul Bangirana and Robert O Opoka and Gregory Saang Park and Andrea L Conroy and Chandy C John},
  journal={Parasite immunology},
  year={2017},
  volume={39 7}
}
Systemic tumour necrosis factor-α (TNF-α) may contribute to the pathogenesis of cerebral malaria (CM) by promoting endothelial activation and parasite sequestration. However, less is known about the role of central nervous system (CNS) TNF-α in CM. We assessed plasma (n=249) and cerebrospinal fluid (CSF) (n=167) TNF-α levels in Ugandan children with CM, plasma TNF-α in Ugandan community control children (n=198) and CSF TNF-α in North American control children who had recovered from leukaemia (n… CONTINUE READING
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