Elevated cerebrospinal fluid sphingomyelin levels in prodromal Alzheimer's disease.

  title={Elevated cerebrospinal fluid sphingomyelin levels in prodromal Alzheimer's disease.},
  author={Marko Kosicek and Henrik Zetterberg and Niels Andreasen and Jasna Peter-Katalini{\'c} and Silva Hecimovic},
  journal={Neuroscience letters},
  volume={516 2},
Alzheimer's disease (AD) is the most common neurodegenerative disorder, but still without known disease mechanism, proper treatment and efficient diagnostic tools for an early stage diagnosis. There is increasing evidence that lipids, especially cholesterol and sphingolipids, may play a role in pathological processes that occur in the AD brain even in very early stages of the disease. However, lipid changes in cerebrospinal fluid (CSF) of individuals with AD have not been well studied. In… CONTINUE READING
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