Elevated cerebrospinal fluid quinolinic acid levels are associated with region-specific cerebral volume loss in HIV infection.

@article{Heyes2001ElevatedCF,
  title={Elevated cerebrospinal fluid quinolinic acid levels are associated with region-specific cerebral volume loss in HIV infection.},
  author={Melvyn P. Heyes and Ronald J Ellis and Lisa Ryan and Meredith E. Childers and Igor Grant and Tanya J Wolfson and Sarah L. Archibald and Terry L. Jernigan},
  journal={Brain : a journal of neurology},
  year={2001},
  volume={124 Pt 5},
  pages={1033-42}
}
Neuronal injury, dendritic loss and brain atrophy are frequent complications of infection with human immunodeficiency virus (HIV) type 1. Activated brain macrophages and microglia can release quinolinic acid, a neurotoxin and NMDA (N-methyl-D-aspartate) receptor agonist, which we hypothesize contributes to neuronal injury and cerebral volume loss. In the present cross-sectional study of 94 HIV-1-infected patients, elevated CSF quinolinic acid concentrations correlated with worsening brain… CONTINUE READING

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