Elevated cerebrospinal fluid neurofilament light levels in patients with amyotrophic lateral sclerosis: a possible marker of disease severity and progression.

@article{Tortelli2012ElevatedCF,
  title={Elevated cerebrospinal fluid neurofilament light levels in patients with amyotrophic lateral sclerosis: a possible marker of disease severity and progression.},
  author={R Tortelli and Maddalena Ruggieri and Rosa Cortese and Eustachio D'Errico and Rosa Capozzo and Antonio Leo and Mariangela Mastrapasqua and Stefano Zoccolella and Rosaria Leante and Paolo Livrea and Giancarlo Logroscino and Isabella Laura Simone},
  journal={European journal of neurology},
  year={2012},
  volume={19 12},
  pages={1561-7}
}
BACKGROUND To date there are no biomarkers with proven reliability as a measure of disease burden in amyotrophic lateral sclerosis (ALS). The aim of our study is to assess the neurofilament light chain (NFL) in cerebrospinal fluid (CSF) samples as a measure of disease activity and progression in ALS. METHODS Thirty-seven consecutive patients with ALS, 25 with chronic inflammatory demyelinating polyneuropathy and 21 with other neurodegenerative diseases were evaluated. CSF NFL levels were… CONTINUE READING