Elevated c-Src is linked to altered cell–matrix adhesion rather than proliferation in KM12C human colorectal cancer cells

@article{Jones2002ElevatedCI,
  title={Elevated c-Src is linked to altered cell–matrix adhesion rather than proliferation in KM12C human colorectal cancer cells},
  author={Robert M. Jones and Egle Avizienyte and Anne W. Wyke and Dewi W Owens and Valerie G Brunton and Margaret C Frame},
  journal={British Journal of Cancer},
  year={2002},
  volume={87},
  pages={1128 - 1135}
}
Elevated expression and/or activity of c-Src, the prototype of the Src family of protein tyrosine kinases, is associated with the development of human colon cancer. However, despite the known pleiotropic effects of these kinases in promoting (a) cell growth downstream of growth factor receptors, and (b) the dynamic regulation of integrin adhesions in fibroblast model systems, their precise role in epithelial cancer cells is unknown. Here we addressed whether elevated expression and activity of… CONTINUE READING