Elevated brain lactate accumulation and increased neurologic deficit are associated with modest hyperglycemia in global brain ischemia.

@article{Natale1990ElevatedBL,
  title={Elevated brain lactate accumulation and increased neurologic deficit are associated with modest hyperglycemia in global brain ischemia.},
  author={J E Natale and S M Stante and L G D'alecy},
  journal={Resuscitation},
  year={1990},
  volume={19 3},
  pages={271-89}
}
This study determined if hyperglycemia: (1) augments ischemic cerebral cortical lactate accumulation during complete cerebral ischemia; and (2) exacerbates subsequent neurologic morbidity and mortality. Dextrose (D5W, n = 8) or normal saline (n = 6) was administered i.v. prior to 10 min of global cerebral ischemia induced by normothermic cardiac arrest in dogs. Before arrest plasma glucose was significantly higher in the D5W-treated group than saline-infused (407 +/- 31 vs. 11 9 +/- 20 mg/dl, P… CONTINUE READING

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