Elevated bone turnover in rat polycystic kidney disease is not due to prostaglandin E2

@article{Weiler2002ElevatedBT,
  title={Elevated bone turnover in rat polycystic kidney disease is not due to prostaglandin E2},
  author={Hope Alberta Weiler and Heather R Kovacs and Evan P Nitschmann and Shirley C Fitzpatrick Wong and Neda Bankovi{\'c}-Cali{\'c} and Malcolm Robert Ogborn},
  journal={Pediatric Nephrology},
  year={2002},
  volume={17},
  pages={795-799}
}
Hyperparathyroidism, secondary to renal disease, is thought to cause high bone turnover via prostaglandin E2 (PGE2). Diets high in n-3 fatty acids reduced PGE2. Thus the objective was to compare the effect of diets high in n-6 and n-3 fatty acids on hyperparathyroidism, bone turnover, and PGE2 in Han:SPRD-cy rats that develop polycystic kidney disease (PKD). Weanling male rats (n=58) were randomized to diets made with either corn or flaxseed oil (5%) for 8 weeks, followed by measurement of… CONTINUE READING

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