Elevated blood pressure, heart rate and body temperature in mice lacking the XLαs protein of the Gnas locus is due to increased sympathetic tone

@inproceedings{Nunn2013ElevatedBP,
  title={Elevated blood pressure, heart rate and body temperature in mice lacking the XLαs protein of the Gnas locus is due to increased sympathetic tone},
  author={Nicolas Nunn and Claire H. Feetham and Jennifer Martin and Richard Barrett-Jolley and Antonius Plagge},
  booktitle={Experimental physiology},
  year={2013}
}
Imbalances of energy homeostasis are often associated with cardiovascular complications. Previous work has shown that Gnasxl-deficient mice have a lean and hypermetabolic phenotype, with increased sympathetic stimulation of adipose tissue. The Gnasxl transcript from the imprinted Gnas locus encodes the trimeric G-protein subunit XLαs, which is expressed in… CONTINUE READING