Elevated blood concentrations of calcineurin inhibitors during diarrheal episode in pediatric liver transplant recipients: involvement of the suppression of intestinal cytochrome P450 3A and P-glycoprotein.

@article{Maezono2005ElevatedBC,
  title={Elevated blood concentrations of calcineurin inhibitors during diarrheal episode in pediatric liver transplant recipients: involvement of the suppression of intestinal cytochrome P450 3A and P-glycoprotein.},
  author={Sachiko Maezono and Koh-ichi Sugimoto and Koh-ichi Sakamoto and Masami Ohmori and Shuji Hishikawa and Koichi Mizuta and Hideo Kawarasaki and Yoshiteru Watanabe and Akio Fujimura},
  journal={Pediatric transplantation},
  year={2005},
  volume={9 3},
  pages={
          315-23
        }
}
We encountered two cases of pediatric living-related liver transplant recipients who showed increases in blood concentration of cyclosporine or tacrolimus, a dual substrate for cytochrome P450 (CYP) 3A and P-glycoprotein (P-gp), during a diarrheal episode. To investigate the effect of intestinal inflammation on the metabolic and efflux pump activities, we conducted the experiments using the lipopolysaccharide (LPS)-induced intestinal damage model. Intestinal epithelial CYP3A activity was… CONTINUE READING
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