Elevated autophagy gene expression in adipose tissue of obese humans: A potential non-cell-cycle-dependent function of E2F1

@inproceedings{Haim2015ElevatedAG,
  title={Elevated autophagy gene expression in adipose tissue of obese humans: A potential non-cell-cycle-dependent function of E2F1},
  author={Yulia Haim and Matthias Bl{\"u}her and Noa Slutsky and Nir Goldstein and Nora Kl{\"o}ting and Ilana Harman-Boehm and Boris Kirshtein and Doron Ginsberg and Martin Gericke and Esther Guiu Jurado and Julia Kovsan and Tanya Tarnovscki and Leonid Kachko and Nava Bashan and Yiftach Gepner and Iris Shai and Assaf Rudich},
  booktitle={Autophagy},
  year={2015}
}
Autophagy genes' expression is upregulated in visceral fat in human obesity, associating with obesity-related cardio-metabolic risk. E2F1 (E2F transcription factor 1) was shown in cancer cells to transcriptionally regulate autophagy. We hypothesize that E2F1 regulates adipocyte autophagy in obesity, associating with endocrine/metabolic dysfunction, thereby, representing non-cell-cycle function of this transcription factor. E2F1 protein (N=69) and mRNA (N=437) were elevated in visceral fat of… CONTINUE READING
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