Elevated atrial natriuretic peptides and early renal failure in type 2 diabetic Goto-Kakizaki rats.

@article{Vesely1999ElevatedAN,
  title={Elevated atrial natriuretic peptides and early renal failure in type 2 diabetic Goto-Kakizaki rats.},
  author={David Lynn Vesely and William Gower and John R. Dietz and Rose M. Overton and Leland C.. Clark and Ebenezer. Antwi and Robert V. Farese},
  journal={Metabolism: clinical and experimental},
  year={1999},
  volume={48 6},
  pages={
          771-8
        }
}
The present investigation was designed to determine if atrial natriuretic peptides (ANPs) are increased in a spontaneous model of non-obese type 2 diabetes, the Goto-Kakizaki (GK) rat. Four peptide hormones originating from the ANP prohormone were increased twofold (P < .05) to sixfold (P < .01) in the circulation of GK rats compared with nondiabetic Wistar rats from which the GK colony was originally derived. Thus, ANP, long-acting natriuretic peptide (LANP), vessel dilator, and kaliuretic… CONTINUE READING
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