Elevated aspartic proteinase secretion and experimental pathogenicity of Candida albicans isolates from oral cavities of subjects infected with human immunodeficiency virus.

@article{Bernardis1996ElevatedAP,
  title={Elevated aspartic proteinase secretion and experimental pathogenicity of Candida albicans isolates from oral cavities of subjects infected with human immunodeficiency virus.},
  author={Flavia de Bernardis and Paola Chiani and Massimo Ciccozzi and Guido Pellegrini and T. Ceddia and G D'Offizzi and Isabella Quinti and Patrick A. Sullivan and Antonio Cassone},
  journal={Infection and immunity},
  year={1996},
  volume={64 2},
  pages={466-71}
}
Isolates of Candida albicans from the oral cavities of subjects at different stages of human immunodeficiency virus (HIV) infection or uninfected controls were examined for (i) production of aspartic proteinase(s), a putative virulence-associated factor(s); (ii) the presence in the fungal genome of two major genes (SAP1 and SAP2) of the aspartic proteinase family; and (iii) experimental pathogenicity in a murine model of systemic infection. It was found that the fungal isolates from symptomatic… CONTINUE READING
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