Elevated arterial cyclic AMP levels during the onset of renal hypertension in rats.

@article{Chatelain1983ElevatedAC,
  title={Elevated arterial cyclic AMP levels during the onset of renal hypertension in rats.},
  author={R. Chatelain},
  journal={Clinical science},
  year={1983},
  volume={64 3},
  pages={
          355-8
        }
}
1. To determine the possible role of arterial cyclic AMP in the pathogenesis of hypertensive vascular hypertrophy and hyperplasia, the changes in the level of this nucleotide were studied during the development of renal hypertension in rats with aortic ligation between the renal arteries. 2. A twofold increase in the cyclic AMP level of the thoracic aorta was observed in 9-day hypertensive rats when compared with sham-operated controls. At this time the total amounts of DNA and collagen were… Expand
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