Elevated alpha-methylacyl-CoA racemase enzymatic activity in prostate cancer.

@article{KumarSinha2004ElevatedAR,
  title={Elevated alpha-methylacyl-CoA racemase enzymatic activity in prostate cancer.},
  author={Chandan Kumar-Sinha and Rajal B Shah and Bharathi Laxman and Scott Arthur Tomlins and Jason Harwood and Werner Schmitz and Ernst Conzelmann and Martin George Sanda and John T. Wei and Mark A. Rubin and Arul M. Chinnaiyan},
  journal={The American journal of pathology},
  year={2004},
  volume={164 3},
  pages={
          787-93
        }
}
Alpha-methylacyl-CoA racemase (AMACR) is a peroxisomal and mitochondrial enzyme involved in the beta-oxidation of branched fatty acids, shown to be elevated in prostate cancer by several recent studies. Sequence variants of AMACR have been linked to prostate cancer risk. Although mRNA transcript, protein, and sequence variants of AMACR have been studied in the context of prostate cancer, AMACR enzymatic activity has not been addressed. Here we present evidence that AMACR activity is… CONTINUE READING
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