Elevated alanine aminotransferase predicts new-onset type 2 diabetes independently of classical risk factors, metabolic syndrome, and C-reactive protein in the west of Scotland coronary prevention study.

@article{Sattar2004ElevatedAA,
  title={Elevated alanine aminotransferase predicts new-onset type 2 diabetes independently of classical risk factors, metabolic syndrome, and C-reactive protein in the west of Scotland coronary prevention study.},
  author={Naveed Sattar and Olga Scherbakova and Ian Ford Ford and Denis St J O'Reilly and Adrian Stanley and E H Forrest and Peter W Macfarlane and Chris J. Packard and Stuart M. Cobbe and James Michael Shepherd},
  journal={Diabetes},
  year={2004},
  volume={53 11},
  pages={2855-60}
}
We examined the association of serum alanine aminotransferase (ALT) with features of the metabolic syndrome and whether it predicted incident diabetes independently of routinely measured factors in 5,974 men in the West of Scotland Coronary Prevention Study. A total of 139 men developed new diabetes over 4.9 years of follow-up. ALT, but not aspartate aminotransferase, levels increased progressively with the increasing number of metabolic syndrome abnormalities from (means +/- SD) 20.9 +/- 7.6… CONTINUE READING

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Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: the Insulin Resistance Atherosclerosis Study

A Festa, R JrD’Agostino, RP Tracy, SM Haffner
Diabetes 51:1131–1137, • 2003
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