Elevated adenosine monophosphate deaminase activity in Alzheimer's disease brain.

@article{Sims1998ElevatedAM,
  title={Elevated adenosine monophosphate deaminase activity in Alzheimer's disease brain.},
  author={Benjamin Sims and Robert E. Powers and Richard L. Sabina and Anne Theibert},
  journal={Neurobiology of aging},
  year={1998},
  volume={19 5},
  pages={385-91}
}
Abnormal elevations in ammonia have been implicated in the pathogenesis of Alzheimer's disease. However, the biochemical mechanism(s) leading to increased ammonia in Alzheimer's disease have not yet been identified. A potential source of increased ammonia production is adenosine monophosphate (AMP) deaminase, an important enzyme in the regulation of the purine nucleotide cycle and adenylate energy charge. AMP deaminase activity is expressed in human brain and converts AMP to inosine… CONTINUE READING
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