Elevated activity of transcription factor nuclear factor of activated T-cells 5 (NFAT5) and diabetic nephropathy.

@article{Yang2006ElevatedAO,
  title={Elevated activity of transcription factor nuclear factor of activated T-cells 5 (NFAT5) and diabetic nephropathy.},
  author={Bingmei Yang and Andrea Dawn Hodgkinson and Peter J. Oates and Hyug Moo Kwon and Beverley Ann Millward and A. G. Demaine},
  journal={Diabetes},
  year={2006},
  volume={55 5},
  pages={1450-5}
}
The expression of aldose reductase is tightly regulated by the transcription factor tonicity response element binding protein (TonEBP/NFAT5) binding to three osmotic response elements (OREs; OREA, OREB, and OREC) in the gene. The aim was to investigate the contribution of NFAT5 to the pathogenesis of diabetic nephropathy. Peripheral blood mononuclear cells (PBMCs) were isolated from the following subjects: 44 Caucasoid patients with type 1 diabetes, of whom 26 had nephropathy and 18 had no… CONTINUE READING
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