Elevated VEGF Levels in Pulmonary Edema Fluid and PBMCs from Patients with Acute Hantavirus Pulmonary Syndrome

@inproceedings{Gavrilovskaya2012ElevatedVL,
  title={Elevated VEGF Levels in Pulmonary Edema Fluid and PBMCs from Patients with Acute Hantavirus Pulmonary Syndrome},
  author={Irina N. Gavrilovskaya and Elena E. Gorbunova and Frederick T. Koster and Erich R. Mackow},
  booktitle={Advances in virology},
  year={2012}
}
Hantavirus pulmonary syndrome is characterized by vascular permeability, hypoxia, and acute pulmonary edema. Vascular endothelial growth factor (VEGF) is induced by hypoxia, potently induces vascular permeability, and is associated with high-altitude-induced pulmonary edema. Hantaviruses alter the normal regulation of β3 integrins that restrict VEGF-directed permeability and hantavirus infected endothelial cells are hyperresponsive to the permeabilizing effects of VEGF. However, the role of… CONTINUE READING
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Pathogenesis of the hantavirus pulmonary syndrome

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