Elevated TGF-beta1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients.

@article{Lee2004ElevatedTS,
  title={Elevated TGF-beta1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients.},
  author={June-Chul Lee and Kyung-Mi Lee and Dong-Wan Kim and Dae Seog Whan Heo},
  journal={Journal of immunology},
  year={2004},
  volume={172 12},
  pages={
          7335-40
        }
}
NK cell function in cancer patients is severely impaired, but the mechanism underlying this impairment is not clearly understood. In this study we show evidence that TGF-beta1 secreted by tumors is responsible for the poor NK lytic activity via down-regulating an NK-activating receptor, NKG2D. The plasma level of TGF-beta1 in human lung cancer or colorectal cancer patients was elevated compared with that in normal volunteers, and this elevation was inversely correlated with surface expression… CONTINUE READING

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