Elevated TGF-beta1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients.

@article{Lee2004ElevatedTS,
  title={Elevated TGF-beta1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients.},
  author={Jong Pill Lee and Kyung-Mi Lee and Dong-Wan Kim and Dae Seog Whan Heo},
  journal={Journal of immunology},
  year={2004},
  volume={172 12},
  pages={
          7335-40
        }
}
NK cell function in cancer patients is severely impaired, but the mechanism underlying this impairment is not clearly understood. In this study we show evidence that TGF-beta1 secreted by tumors is responsible for the poor NK lytic activity via down-regulating an NK-activating receptor, NKG2D. The plasma level of TGF-beta1 in human lung cancer or colorectal cancer patients was elevated compared with that in normal volunteers, and this elevation was inversely correlated with surface expression… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 154 CITATIONS

FILTER CITATIONS BY YEAR

2004
2019

CITATION STATISTICS

  • 9 Highly Influenced Citations

  • Averaged 14 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 35 REFERENCES

Transforming growth factor 1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells

  • R. Castriconi, C. Cantoni, +7 authors A. Moretta
  • Proc. Natl. Acad. Sci. USA
  • 2003
1 Excerpt

Similar Papers

Loading similar papers…