Elevated TATA-binding protein expression drives vascular endothelial growth factor expression in colon cancer


The TATA-binding protein (TBP) plays a central role in eukaryotic gene transcription. Given its key function in transcription initiation, TBP was initially thought to be an invariant protein. However, studies showed that TBP expression is upregulated by oncogenic signaling pathways. Furthermore, depending on the cell type, small increases in cellular TBP… (More)
DOI: 10.18632/oncotarget.16384