Corpus ID: 195714442

Elevated Serum IL-6 , IL-8 , Monocyte Chemoattractant Protein-1 , CRP , and IFN-Levels in 10-to 11-Year-Old Boys with Increased BMI

  title={Elevated Serum IL-6 , IL-8 , Monocyte Chemoattractant Protein-1 , CRP , and IFN-Levels in 10-to 11-Year-Old Boys with Increased BMI},
  author={Liina Utsal and Vallo Tillmann and Mihkel Zilmer and Jarek M{\"a}estu and P. Purge and Jaak J{\"u}rim{\"a}e and Meeli Saar and E L{\"a}tt and Katre Maasalu and Toivo J{\"u}rim{\"a}e},
Background/Aims: Many inflammation parameters are associated with obesity, but few comparable data are found in youth. This study aims to characterize the differences in serum levels of 13 biochemical inflammatory markers between boys with increased BMI and boys with normal BMI, and examine the relationships between inflammation markers, skinfold thicknesses, and body composition. Participants/ Methods: The participants were 38 boys (BMI above 85th percentile) and 38 boys (normal BMI) at the… Expand

Tables from this paper


Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-α and IL-6
The positive associations of obesity and visceral adiposity with elevated cytokine levels suggest the importance of reducing obesity and abdominal fat distribution to prevent elevations in cytokine Levels. Expand
Increased activity of interleukin-23/interleukin-17 proinflammatory axis in obese women
Interleukin-23/IL-17 axis is stimulated in obese women independently of the increase in abdominal fat, insulin resistance, leptin and MIF levels. Expand
IL-6, IL-8 and IL-10 Levels in Healthy Weight and Overweight Children
The effects of obesity on IL-6, IL-8 and IL-10 levels vary with age and sex, with owt/ob girls at 15 years showing raised IL- 6, IL the 8 and IL the 10 levels compared to healthy weight girls. Expand
[Selected cytokines (Il-6, Il-8, Il-10, MCP-1, TNF-alpha) in children and adolescents with atherosclerosis risk factors: obesity, hypertension, diabetes].
Children and adolescents with obesity, obesity accompanying by hypertension and diabetes have elevated levels of IL-6 and TNF-alpha, which can confirm the presence of inflammatory process in early phases of atherosclerosis. Expand
Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion.
Fasting plasma IL- 6 concentrations are positively related to adiposity and negatively related to insulin action in Pima Indians, and the relationship between IL-6 and insulin action seems to be mediated through adiposity. Expand
Low-grade inflammation, obesity, and insulin resistance in adolescents.
There is evidence that IL-6, IL-18, IP-10, and adiponectin (inversely) are associated with insulin resistance and that these associations can mainly be attributed to obesity. Expand
Changes in adipose-derived inflammatory cytokines and chemokines after successful lifestyle intervention in obese children.
This study demonstrates significant correlations between different metabolic risk factors at baseline and after changes of weight status and that weight loss in obese children reduces low-grade inflammation, insulin resistance, and blood pressure. Expand
Increased T-helper interferon-gamma-secreting cells in obese children.
In obese children, a shift to Th1-cytokine profile dominated by the production of IFN-gamma is related to insulin resistance as well as to NASH independently of anthropometric features and other metabolic characteristics. Expand
Elevation of serum C-reactive protein levels is associated with obesity in boys.
The findings that CRP is one of the useful indices of childhood obesity that would affect the progression to future atherosclerotic disease are supported and a strategy of preventing obesity from childhood would contribute to a drop in the future incidence of metabolic syndromes. Expand
High-sensitive C-reactive protein, tumor necrosis factor alpha, and cardiovascular risk factors before and after weight loss in obese children.
The chronic inflammation markers TNF-alpha and hsCRP were independent of lipids, blood pressure, and insulin resistance index and Obese children demonstrated significantly higher levels of hs CRP and T NF-alpha compared with nonobese children. Expand