Elevated SOCS3 and altered IL-6 signaling is associated with age-related human muscle stem cell dysfunction.

@article{McKay2013ElevatedSA,
  title={Elevated SOCS3 and altered IL-6 signaling is associated with age-related human muscle stem cell dysfunction.},
  author={Bryon R. McKay and Daniel I. Ogborn and Jeff M. Baker and Kyle G. Toth and Mark A Tarnopolsky and Gianni Parise},
  journal={American journal of physiology. Cell physiology},
  year={2013},
  volume={304 8},
  pages={C717-28}
}
Aging is associated with increased circulating interleukin-6 (IL-6) and a reduced myogenic capacity, marked by reduced muscle stem cell [satellite cell (SC)] activity. Although IL-6 is important for normal SC function, it is unclear whether elevated IL-6 associated with aging alters SC function. We hypothesized that mild chronically elevated IL-6 would be associated with a blunted SC response through altered IL-6 signaling and elevated suppressor of cytokine signaling-3 (SOCS3) in the elderly… CONTINUE READING
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